Custom Enzymes and Inhibitors
Selleck Chemical LLC GSK690693 50mg 937174-76-0
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam A 83-01, ALK4, 5 and 7 kinase inhibitor, 1MG
MW 421.5 Da, Purity >98%. Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC₅₀ values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Pristimerin (Celastrol methyl ester) | 1258-84-0 | MFCD01711331 | 464.64 | 50 MG
Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC50 of 93 nM. It inhibits MGL rapidly, reversibly, and non-competitively, possibly through a polar interaction with Cys208. Pristimerin also inhibits HFLS-RA and HUVEC cell viability in a dose- and time-dependent manner, and decreases VEGF-induced autophosphorylation of VEGFR2, attenuating the VEGFR2-mediated signaling pathway. Furthermore, Pristimerin inhibits inflammation and tumor angiogenesis, reducing vessel density in synovial membrane tissues of inflamed joints and lowering the expression of pro-angiogenic factors like TNF-α, Ang-1, and MMP-9 in sera.
- Potent and reversible monoacylglycerol lipase (MGL) inhibitor.
- Inhibits HFLS-RA and HUVEC cell viability.
- Attenuates VEGFR2-mediated signaling pathway.
- Inhibits inflammation and tumor angiogenesis.
Selleck Chemical LLC NVP-AEW541 2mg 475489-16-8 AEW541
NVP-AEW541 is a potent inhibitor of IGF-1R/InsR with IC50 of 150 nM/140 nM in cell-free assays, greater potency and selectivity for IGF-1R in a cell-based assay. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC SNS-032 (BMS-387032) 50mg 345627-80-7
SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Quizartinib (AC220) 5mg 950769-58-1
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFR?, PDGFR?, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Bosutinib (SKI-606) 10mg 380843-75-4
Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC An ATP-competitive, potent CDK1 inhibitor 872573-93-8. MFCD17392573
An ATP-competitive, potent CDK1 inhibitor 872573-93-8. MFCD17392573
Apexbio Technology LLC ICG 001, 10mg. Cas: 847591-62-2 MFCD: MFCD12196918. Wnt/β-catenin pathway inhibitor
Wnt/ Beta -catenin pathway inhibitor blocking Beta -catenin/CBP interaction 847591-62-2. MFCD12196918
Medchemexpress LLC HY-103409 5mg Medchemexpress, ABT-724 (trihydrochloride) CAS:587870-77-7 Purity:>98%
Medchemexpress, HY-103409 5mg ABT-724 (triHCl) CAS:587870-77-7 ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC KU-60019 10mg 925701-49-1
KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Roscovitine (Seliciclib) 10mg 186692-46-6 CYC202
Roscovitine (Seliciclib, CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 ?M, 0.7 ?M and 0.16 ?M in cell-free assays. It shows little effect on CDK4/6. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.